Helichrysum (Helichrysum italicum) or Immortelle belongs to the sunflower family (Asteraceae) and is extensively cultivated in Greek countryside. According to folk tales, the blossom of helichrysum was dried and offered as a gift to gods. Today, it plays a very important role in traditional medicine of countries around the Mediterranean Sea. Meanwhile, it becomes even more popular worldwide. Helichrysum is known for its therapeutic properties and its essential oil is used as a natural antibiotic. Not only the blossom but also the leaves are widely used at the preparation of therapeutic remedies. Nevertheless, it is widely known for its essential oil, which is used as a sunburn soother and in healing of various skin conditions, such as acne and fungal infections. However, its therapeutic effect does not end there. Helichrysum essential oil relieves digestive-related pain and is also used as a diuretic. In addition, it is used as a natural painkiller in cases of musculoskeletal disorders.